The Role Of Latin American Banks In The Region’s Currency Crises

The frequency of currency crises in Latin America has not abated in the last few years, as the Mexican Peso crises of 1982 and 1995, the Brazilian Real Crisis of 1998 and the Argentine Peso crisis of 2001 attest. Although many factors are involved in these crises, Latin American banks have played an important, yet previously unstudied role in the frequency and severity of the region’s financial crises. This paper examines four of the most recent currency crises in the region to determine if there are any commonalities or root causes to be found in the region’s banking system. It is found that, indeed, the region’s banks have had a profound role.Currency crises, Latin America, Banking

The external impacts of Central Bank independence

The term "central bank independence" (or abbreviated, CBI) can be broadly defined as the degree of freedom of the central bank to pursue monetary policy without interference from political considerations. The idea of central bank independence has been widely accepted over the last several decades by many countries around the world, both developed and developing. Since being first written about academically in the late 1980s, many countries have come to adopt this policy and many governments have come to recognize this as standard procedure. As such, many countries around the world granted autonomy to their central banks during the 1980s and 1990s. The majority of past studies have examined primarily the impact of central bank independence on inflation. however, the additional theoretical benefits are much more far reaching, the result of a more stable and prosperous macroeconomic environment. Additionally, there is only now sufficient data to empirically determine whether many of these claims are true. This study examines central bank independence in developing countries of Latin America and Asia as well as selected developed countries to determine what actual impact an autonomous central bank has had. It also examines such phenomena as financial crises (including the current global crisis of 2008-2009), inflation targeting, legal systems, country development and fiscal policy to determine the effects of these items on not only inflation, but the broad spectrum of macroeconomic outcomes. Although there is some empirical evidence to support the benefits of central bank independence, it is limited in scope to certain areas.O termo "independência do banco central" (ou IBC) pode ser amplamente definido como o grau de liberdade que o banco central possui para seguir sua política monetária sem a interferência de considerações políticas. A ideia da independência do banco central foi aceita nas últimas décadas por muitos países ao redor do mundo, tanto desenvolvidos como em desenvolvimento. Desde a primeira literatura acadêmica a respeito no final dos anos 80, muitos países começaram a adotar essa política e muitos governos a reconheceram como padrão. Assim, muitos países ao redor do mundo concederam autonomia a seus bancos centrais nos anos 80 e 90. A maior parte dos estudos existentes investigou principalmente o impacto da independência do banco central na inflação. Porém, os benefícios teóricos adicionais vão muito além, resultado de um ambiente macroeconômico mais estável e próspero. Ademais, somente agora há dados suficientes para a determinação empírica da veracidade de muitas dessas alegações. Este estudo investiga a independência dos bancos centrais em países em desenvolvimento na América Latina e na Ásia, além de determinados países desenvolvidos, para determinar o real impacto de um banco central autônomo. Também examina fenômenos como crises financeiras (inclusive a crise global em curso no período 2008-2009), estabelecimento de metas de inflação, sistemas legais, desenvolvimento dos países e política fiscal para determinar os efeitos destes itens não somente na inflação, mas no espectro amplo de resultados macroeconômicos. Apesar de haver evidências empíricas para apoiar os benefícios da independência do banco central, seu escopo é limitado a determinadas áreas

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy.

The antitumor efficacy of cancer immunotherapy can correlate with the presence of certain bacterial species within the gut microbiome. However, many of the molecular mechanisms that influence host response to immunotherapy remain elusive. In this study, we show that members of the bacterial genus Enterococcus improve checkpoint inhibitor immunotherapy in mouse tumor models. Active enterococci express and secrete orthologs of the NlpC/p60 peptidoglycan hydrolase SagA that generate immune-active muropeptides. Expression of SagA in nonprotective E. faecalis was sufficient to promote immunotherapy response, and its activity required the peptidoglycan sensor NOD2. Notably, SagA-engineered probiotics or synthetic muropeptides also augmented anti-PD-L1 antitumor efficacy. Taken together, our data suggest that microbiota species with specialized peptidoglycan remodeling activity and muropeptide-based therapeutics may enhance cancer immunotherapy and could be leveraged as next-generation adjuvants

The external impacts of Central Bank independence Os impactos externos da independência dos Bancos Centrais

The term "central bank independence" (or abbreviated, CBI) can be broadly defined as the degree of freedom of the central bank to pursue monetary policy without interference from political considerations. The idea of central bank independence has been widely accepted over the last several decades by many countries around the world, both developed and developing. Since being first written about academically in the late 1980s, many countries have come to adopt this policy and many governments have come to recognize this as standard procedure. As such, many countries around the world granted autonomy to their central banks during the 1980s and 1990s. The majority of past studies have examined primarily the impact of central bank independence on inflation. however, the additional theoretical benefits are much more far reaching, the result of a more stable and prosperous macroeconomic environment. Additionally, there is only now sufficient data to empirically determine whether many of these claims are true. This study examines central bank independence in developing countries of Latin America and Asia as well as selected developed countries to determine what actual impact an autonomous central bank has had. It also examines such phenomena as financial crises (including the current global crisis of 2008-2009), inflation targeting, legal systems, country development and fiscal policy to determine the effects of these items on not only inflation, but the broad spectrum of macroeconomic outcomes. Although there is some empirical evidence to support the benefits of central bank independence, it is limited in scope to certain areas.<br>O termo "independência do banco central" (ou IBC) pode ser amplamente definido como o grau de liberdade que o banco central possui para seguir sua política monetária sem a interferência de considerações políticas. A ideia da independência do banco central foi aceita nas últimas décadas por muitos países ao redor do mundo, tanto desenvolvidos como em desenvolvimento. Desde a primeira literatura acadêmica a respeito no final dos anos 80, muitos países começaram a adotar essa política e muitos governos a reconheceram como padrão. Assim, muitos países ao redor do mundo concederam autonomia a seus bancos centrais nos anos 80 e 90. A maior parte dos estudos existentes investigou principalmente o impacto da independência do banco central na inflação. Porém, os benefícios teóricos adicionais vão muito além, resultado de um ambiente macroeconômico mais estável e próspero. Ademais, somente agora há dados suficientes para a determinação empírica da veracidade de muitas dessas alegações. Este estudo investiga a independência dos bancos centrais em países em desenvolvimento na América Latina e na Ásia, além de determinados países desenvolvidos, para determinar o real impacto de um banco central autônomo. Também examina fenômenos como crises financeiras (inclusive a crise global em curso no período 2008-2009), estabelecimento de metas de inflação, sistemas legais, desenvolvimento dos países e política fiscal para determinar os efeitos destes itens não somente na inflação, mas no espectro amplo de resultados macroeconômicos. Apesar de haver evidências empíricas para apoiar os benefícios da independência do banco central, seu escopo é limitado a determinadas áreas

Enhancing the Validity and Utility of Randomized Clinical Trials in Addictions Treatment Research: II. Participant Samples and Assessment

Purpose: This paper is the second in a series that describes strategies for optimizing the validity and utility of randomized clinical trials (RCTs) in addictions treatment research. Whereas the first paper focused on treatment implementation and research design, here we address issues pertaining to participant samples and assessment methods. Scope: With respect to participant samples, sections focus on the definition of study populations; informed consent; sample size and statistical power; recruitment and enrollment; sample retention; and participant tracking systems. Assessment topics include eligibility screening and baseline assessment; treatment‐related variables; outcome measures; the frequency of follow‐up evaluation; and assessment process. A final section highlights the importance of pilot testing. Conclusions: Sample recruitment and retention strategies are needed that safeguard both internal and external validity. Daily estimation assessment procedures are recommended because of their versatility for creating a range of outcome measures. Assessment batteries should include measures that permit the investigation of treatment processes and mechanisms of action